Héctor Climente-González

Senior Scientist at Isomorphic Labs. London, United Kingdom.

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With over 13 years of experience in computational biology and applied statistics, I apply AI/ML to drug discovery, with a focus on genetics, explainable ML, and systems biology.

Prior to joining Isomorphic Labs, I served as Systems Biology Lead at Novo Nordisk, where I developed solutions for target identification and maturation.

Following a double degree in Biotechnology and Biochemistry and a Master’s in Bioinformatics, I specialized in AI/ML applications to biology, particularly graph-based methods for genetic studies (PhD at CBIO with Chloé-Agathe Azencott) and novel AI/ML methods for feature selection (Postdoc at RIKEN AIP with Makoto Yamada). Check out my publications and GitHub profile for more details.

I’m an advocate for reproducible research and well-engineered research solutions, with a focus on Nextflow pipelines. I’m detail-oriented, proactive, and wired to fix what’s broken—ideally before anyone else notices.

news

Nov 24, 2025 I joined Isomorphic Labs as Senior Scientist.
Aug 26, 2025 Our algorithm on feature selection via sparse minimum Redundancy Maximum Relevance is out! This work was driven by Peter Naylor.
Jul 01, 2025 I was promoted to Systems Biology Lead. I will deliver Systems Biology capabilities for early target discovery and maturation.

latest posts

selected publications

  1. The functional impact of alternative splicing in cancer
    Héctor Climente-González, Eduard Porta-Pardo, Adam Godzik, and 1 more author
    Cell reports, 2017
  2. Block HSIC Lasso: model-free biomarker detection for ultra-high dimensional data
    Héctor Climente-González, Chloé-Agathe Azencott, Samuel Kaski, and 1 more author
    Bioinformatics, 2019
  3. Interpretable network-guided epistasis detection
    Diane Duroux, Héctor Climente-González, Chloé-Agathe Azencott, and 1 more author
    GigaScience, 2022
  4. A network-guided protocol to discover susceptibility genes in genome-wide association studies using stability selection
    Héctor Climente-González, Chloé-Agathe Azencott, and Makoto Yamada
    STAR protocols, 2023