Héctor Climente-González
Senior Scientist at Isomorphic Labs. London, United Kingdom.
With over 13 years of experience in computational biology and applied statistics, I apply AI/ML to drug discovery, with a focus on genetics, explainable ML, and systems biology.
Prior to joining Isomorphic Labs, I served as Systems Biology Lead at Novo Nordisk, where I developed solutions for target identification and maturation.
Following a double degree in Biotechnology and Biochemistry and a Master’s in Bioinformatics, I specialized in AI/ML applications to biology, particularly graph-based methods for genetic studies (PhD at CBIO with Chloé-Agathe Azencott) and novel AI/ML methods for feature selection (Postdoc at RIKEN AIP with Makoto Yamada). Check out my publications and GitHub profile for more details.
I’m an advocate for reproducible research and well-engineered research solutions, with a focus on Nextflow pipelines. I’m detail-oriented, proactive, and wired to fix what’s broken—ideally before anyone else notices.
news
| Nov 24, 2025 | I joined Isomorphic Labs as Senior Scientist. |
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| Aug 26, 2025 | Our algorithm on feature selection via sparse minimum Redundancy Maximum Relevance is out! This work was driven by Peter Naylor. |
| Jul 01, 2025 | I was promoted to Systems Biology Lead. I will deliver Systems Biology capabilities for early target discovery and maturation. |
latest posts
| Oct 10, 2025 | Independent Component Analysis |
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| Sep 20, 2025 | How do vector databases work? |
| Aug 01, 2025 | Cross-entropy. Intuition and applications. |
selected publications
- The functional impact of alternative splicing in cancerCell reports, 2017
- Block HSIC Lasso: model-free biomarker detection for ultra-high dimensional dataBioinformatics, 2019
- Interpretable network-guided epistasis detectionGigaScience, 2022
- A network-guided protocol to discover susceptibility genes in genome-wide association studies using stability selectionSTAR protocols, 2023