I am a PhD student at Center for computational biology which is a joint research unit involving Mines ParisTech, Institut Curie and INSERM. The center is dedicated to epidemiology, bioinformatics and computational systems biology of cancer. I am co-supervised by Chloé-Agathe Azencott and Véronique Stoven.
The big question of my thesis is the missing heritability problem, the discordance between the estimated genetic determination of a phenotype, and the actual genetic factors we can associate with it. The community has come up with several possible explanations, and during my thesis I intend on exploring two of them: epistasis and the high p, low n curse. To do so, I am carrying out GWAS which include a priori knowledge, namely biological networks that give a context to every SNP. In consequence, we can carry out context-dependent statistics, where we can fine tune the significance threshold for each individual SNP. Currently we are applying these approaches to find new biomarkers of familial breast cancer.
I got a double degree on Biotechnology and Biochemistry in Universitat Autònoma de Barcelona in 2012. After a turbulent, love-hate relationship with experimental biology, I got into computational biology, obtaining a MSc in Bioinformatics at Universitat Pompeu Fabra in 2014. I kept exploring my profesional and research interests, finally deciding to start a PhD in CBIO, a machine learning-oriented group directed by Jean-Philippe Vert.